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TIGAR The β-strands β6 and β7 extend longer at the remote side of the central β-sheet and the long loop insertion between α7 and β4 is not observed in PhoE.
β-sheets discussed are shown in corn flower blue and α helices in yellow. Two phosphate molecules bound are shown in spacefilling view.
Hua Li and Gerwald Jogl
Structural and Biochemical Studies of TIGAR(TP53-induced Glycolysis and Apoptosis Regulator The Journal of Biological Chemistry, 284,1748-1754
(PubMed) 3E9D (PDB) |
PhoE Phosphatase In
PhoE, two helices occupy the position of the TIGAR helix α6 and
the following loop region is longer and forms and additional
short helical turn. In active site, the position of first
phosphate is nearly identical.
The second phosphate binding is occupied by
Val208.
Alpha helices discussed are shown in orange. Phosphate molecule bound is shown in spacefilling view. Daniel J. Rigden, James E. Littlejohn, Keith Henderson, Mark J.Jedrzejas Structures of Phosphate and Trivanadate Complexes of Bacillus stearothermophilus Phosphatase PhoE: Structural and Functional Analysis in the Cofactor-dependent Phosphoglycerate Mutase Superfamily
Journal of Molecular Biology, 325, 411-420
(PubMed) 1H2E (PDB) |